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Vascular diseases, such as coronary, cerebrovascular or peripheral vascular diseases, involve reduced blood flow in the body, which can be caused by many factors such as inflammation, intimal thickening, or blood pressure, thus leading to ischemia and hypoxia. Vascular diseases can be categorized into two types. The first type occurs through a physiological process that is not pathological, i.e., neovascularization, wherein a new blood vessel, which is typically a capillary, is formed through endothelial cell proliferation. The second type is pathological, such as atherosclerosis, wherein there is thickening of the intimal layer of the vessel, which may also contain a number of thrombi.
For example, atherosclerosis is the hardening of the arteries and is caused by the development of plaque in the arteries, which reduces the flow of blood in the vessels, leading to a decreased oxygen supply to the tissues. If this process continues for a long period of time, the result may be an ischemic injury to tissue supplied by the affected artery. Atherosclerosis is usually chronic and may eventually cause symptoms such as angina, hypertension, or acute thrombotic events such as stroke or myocardial infarction. Atherosclerotic lesions contain foamy macrophages and proliferating smooth muscle cells. The earliest lesions form in response to damage to the intimal lining of the arterial wall and, because of the persistence of the proliferating cells and the lack of a synthetic phenotype, the lesions tend to be brittle. The injury involved may be a result of a high blood lipid or lipoprotein level, trauma, infection, or smooth muscle cell proliferation.
The most common method of treating stenosis is balloon angioplasty. In this method, a catheter is inserted into a femoral artery and is advanced up the aorta and over the aortic arch, into a coronary artery, such as the left or right coronary artery. A catheter with an inflatable balloon at its distal end is advanced through the vasculature past the obstruction and the balloon is inflated, opening the obstructed artery and permitting increased blood flow.
This method suffers from a number of drawbacks. The lesions may be caused by a narrowing of the vessel, but the balloon in the catheter can only expand within a certain length of the vessel, typically less than


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